CAR T logistics is an interplay of precision, safety, and personalization. It demands state-of-the-art cold chain infrastructure, seamless coordination, regulatory diligence, and end-to-end visibility. As the field evolves, advancements in automation, regional manufacturing, and supply chain technology promise to make these life-saving therapies more accessible and efficient.

🧰 Why Choose Us?

🩸 Vein to Vein Journey

• Leukapheresis: T cells are harvested from the patient.

• Cryo shipment to Manufacturing: These cells are cryopreserved (often at –150 °C) and transported to a GMP-certified manufacturing site Supply Chain DiveWikipedia.

• Genetic Modification & Expansion: T cells are modified using viral vectors and expanded into millions of CAR T cells.

• Return Shipment & Infusion: The final product is cryopreserved again and shipped back under strict temperature control for infusion into the patient Supply Chain DivePharmaCommerceWikipedia.

❄️ Cold Chain Integrity

• Cryogenic Handling: Maintaining ultra-low temperatures is critical. Logistics providers use specialized containers and dry ice or nitrogen-based systems PharmaCommerceSupply Chain Dive.

• Re charging Infrastructure: Longer routes may require cryo charging stations for re liquid nitrogen supplementation mid transit PMC.

🔒 Chain of Custody & Identity (CoC & CoI)

• Patient Identity Preservation: Since each therapy is patient specific, maintaining chain of identity is vital. Unique identifiers and tracking systems are used during the entire transport and handling process Insights Bio.

• Robust Traceability: This includes regulatory compliance, temperature monitoring, and documentation across handoffs PMCPharmaCommerce.

📅 Scheduling & Process Coordination

• Tight Time Windows: Manufacturing may take ~14–22 days—a timeline that’s continuously being reduced to accelerate treatment delivery ReutersPMC.

• Orchestrated Delivery: Logistics must align with patient conditioning regimens and treatment slot availability, requiring precise scheduling and coordination across clinical and manufacturing units PharmaCommerce.

📜 Regulatory & Operational Complexity

• GMP Compliance: Manufacturing facilities must adhere to Good Manufacturing Practices. Any deviation can halt production or delay therapy Supply Chain Dive.

• Cross-border Regulations: Varying customs and biospecimen regulations complicate international shipment PMC.

• Scalability Challenges: The highly manual, personalized nature of CAR T processes limits scalability and increases cost Insights Bio